abstract：:Normal pregnancy is associated with an increasing state of activation of the haemostatic system. This activation state is excessive in women with placenta-mediated pregnancy complications (PMPCs), including preeclampsia (PE). Platelet activation plays a crucial pathophysiological role in PE. The very early activation ...

journal_title：Thrombosis research

authors： Gris JC,Bouvier S,Cochery-Nouvellon É,Mercier É,Mousty È,Pérez-Martin A

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Immune thrombocytopenia (ITP) is an immune-mediated bleeding disorder in children. Activated T cells have been shown to play important roles in ITP. The aims of this study were to evaluate whether these T cell activation markers could be used as indicators to differentiate ITP patients from controls, and to ...

journal_title：Thrombosis research

authors： Chen Y,Zhou Y,Chen P,Zhang P,Jia M,Tang Y

更新日期：2019-08-01 00:00:00

abstract：:Normal haemostasis requires maintenance of a careful equilibrium between the necessity to clot when bleeding and the retention of fluid phase at all other times. Disruption of this equilibrium can result in catastrophic outcomes, e.g. acute myocardial infarction and pulmonary embolism. However, despite the significant...

journal_title：Thrombosis research

authors： Lim HY,O'Malley C,Donnan G,Nandurkar H,Ho P

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Direct oral anticoagulants (DOACs) are high risk medications with short half-lives making adherence vitally important. Global measures for adherence have been described; however, there is a lack of patient-level data on adherence. METHODS:This prospective, single-center study in an interdisciplinary interna...

journal_title：Thrombosis research

authors： Talana AS,Huber K,Sorin M,Stalvey C,Davis K,Dietrich E

更新日期：2019-07-01 00:00:00

abstract：:Megakaryocytes (MKs) are widely known as the progenitor cells of platelets. These large, polyploid cells are a derivative of the hematopoietic stem cell (HSC), and reside in the bone marrow, lining blood vessel walls where they release their platelet progeny into circulation. Although little is known about how MKs dif...

journal_title：Thrombosis research

authors： Couldwell G,Machlus KR

更新日期：2019-07-01 00:00:00

abstract：:Venous thromboembolism (VTE) affects approximately 1 per 1000 persons annually. Although patients are increasingly treated with direct oral anticoagulants, many patients continue to be anticoagulated with vitamin K antagonists (VKA). The most important adverse events during VKA treatment, bleeding and the risk of recu...

journal_title：Thrombosis research

authors： Schmidt DE,Chaireti R,Bruzelius M,Holmström M,Antovic J,Ågren A

更新日期：2019-06-01 00:00:00

abstract：OBJECTIVE:To explore the functional exercises of deep breathing and lower limb motions for the prevention of venous thrombosis in patients undergoing major surgery for gynecologic malignancy. METHODS:All eligible patients admitted to the gynecologic oncology unit were randomized into the study and control groups. A co...

journal_title：Thrombosis research

authors： Guo M,Lu L,Sun Y,Li L,Wu M,Lang J

更新日期：2019-06-01 00:00:00

abstract：INTRODUCTION:Sepsis is frequently complicated by disseminated intravascular coagulation (DIC), which promotes multiple organ dysfunctions and significantly increase the mortality of patients with sepsis. How bacteria cause DIC is not fully understood. Outer membrane vesicles (OMVs) are membrane-enclosed microvesicles r...

journal_title：Thrombosis research

authors： Wang E,Liu Y,Qiu X,Tang Y,Wang H,Xiao X,Chen F,Lu B

更新日期：2019-06-01 00:00:00

abstract：:ACS patients undergoing percutaneous coronary intervention (PCI) when treated with bivalirudin and clopidogrel had increased frequency of early stent thrombosis. 24 patients referred for intervention with planned bivalirudin therapy, not previously treated with a P2Y12 inhibitor and not receiving heparins or αIIbβ3 in...

journal_title：Thrombosis research

authors： Kimmelstiel C,Stevenson R,Nguyen N,Van Doren L,Zhang P,Perkins J,Kapur NK,Weintraub A,Castaneda V,Kuliopulos A,Covic L

更新日期：2019-05-01 00:00:00

abstract：:Trimethylamine-N-oxide (TMAO), one of the products in choline metabolite, is recently reported to be associated with cardiovascular diseases (CVD) that mainly attribute to atherothrombosis. However, the mechanisms how TMAO functions in the pathogenesis of CVD and atherothrombosis remain elusive. Tissue factor (TF) has...

journal_title：Thrombosis research

authors： Cheng X,Qiu X,Liu Y,Yuan C,Yang X

更新日期：2019-05-01 00:00:00

abstract：INTRODUCTION:Early achievement of therapeutic INR leads to shorter hospital stay and lesser cost. Two warfarin initiation nomograms (10 mg nomogram and 5 mg nomogram) are widely used but it is not yet clear which one is better. They have been validated in the West but there are no studies from India. We undertook this ...

journal_title：Thrombosis research

authors： Naik D S,Pillai VM,Adole PS

更新日期：2019-04-01 00:00:00

abstract：INTRODUCTION:Antithrombin deficiency is associated with increased risk of venous thromboembolism (VTE). We aimed to identify variants causing antithrombin deficiency in a Danish population. MATERIALS AND METHODS:We performed Sanger sequencing and, in relevant cases, multiplex ligation-dependent probe amplification ana...

journal_title：Thrombosis research

authors： Kjaergaard AD,Larsen OH,Hvas AM,Nissen PH

更新日期：2019-03-01 00:00:00

abstract：INTRODUCTION:Only sparse information exists on the use of direct oral anticoagulant (DOAC) testing and the impact on clinical management. Here, we evaluated the clinical impact of DOAC measurements in a real-life clinical setting. Moreover, number of tests performed in relation to number of DOAC-treated patients was ev...

journal_title：Thrombosis research

authors： Winther-Larsen A,Hvas AM

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:Clauss fibrinogen assay (CFA) is widely used as a screening test to detect fibrinogen disorders. However, CFA alone cannot distinguish quantitative and qualitative defects because it depends on functional fibrinogen activity (Ac), and fibrinogen antigen (Ag) determination is required to classify fibrinogen d...

journal_title：Thrombosis research

authors： Suzuki A,Suzuki N,Kanematsu T,Shinohara S,Arai N,Kikuchi R,Matsushita T

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Bypassing agents are the first line therapy in patients with acquired haemophilia A (AHA). Activated prothrombin complex concentrate (aPCC) proved to be effective as initial treatment, but 20% of patients (pts) had relapses. aPCC as short-term prophylaxis to reduce subsequent bleeds is still not clear. AIM:...

journal_title：Thrombosis research

authors： Zanon E,Pasca S,Siragusa S,Napolitano M,Santoro C,Mameli L,Rocino A,FAIR Study Group.

更新日期：2019-02-01 00:00:00

abstract：INTRODUCTION:A higher level of health insurance coverage may be related to better quality of care and outcomes. Whether insurance status is associated with anticoagulation quality and clinical outcomes in patients with venous thromboembolism (VTE) is unknown. METHODS:We studied 819 elderly patients treated with vitami...

journal_title：Thrombosis research

authors： Zumbrunn B,Stalder O,Méan M,Limacher A,Tritschler T,Rodondi N,Aujesky D

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Whether antibodies directed to β2-Glycoprotein I (aβ2GPI) are responsible for LA activity is not well defined. However, in the absence of such antibodies the molecule responsible for LA phenomenon is unknown. OBJECTIVE:The aim of this study was the biochemical identification of the target antigen epitope of...

journal_title：Thrombosis research

authors： Pengo V,Del Ross T,Ruffatti A,Bison E,Cattini MG,Pontara E,Testa S,Legnani C,Pozzi N,Peterle D,Acquasaliente L,De Filippis V,Denas G

更新日期：2018-12-01 00:00:00

abstract：INTRODUCTION:Tumor necrosis factor-alpha (TNF-α) exerts a critical role in inflammatory events through two distinct receptors, TNFR1 and TNFR2. Platelets have been recognized as important inflammatory cells, but little is known about the effects of TNF-α on the platelet activity. OBJECTIVES:In the present study we hav...

journal_title：Thrombosis research

authors： Bonfitto PHL,Naime ACA,Lopes-Pires ME,Goulart G,Mendes-Silverio CB,Bueno PI,Castilho RF,Antunes E,Marcondes S

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:Atherosclerosis occurs as a result of a chronic inflammatory response in the arterial wall associated with an increased uptake of low-density lipoprotein by macrophages and the subsequent transformation of this lipoprotein into foam cells. It has been found that miR-188-3p can suppress autophagy and myocardi...

journal_title：Thrombosis research

authors： Zhang XF,Yang Y,Yang XY,Tong Q

更新日期：2018-11-01 00:00:00

abstract：INTRODUCTION:Endothelial dysfunction plays an essential role in the pathogenesis of sepsis. The study aimed to illustrate the associations between the dynamic change (from day 1 to day 7) in biomarker concentration of endothelial dysfunction and outcomes in severe sepsis and septic shock in the intensive care unit (ICU...

journal_title：Thrombosis research

authors： Fang Y,Li C,Shao R,Yu H,Zhang Q

更新日期：2018-11-01 00:00:00

abstract：INTRODUCTION:Different Klebsiella pneumoniae strains carry different virulence factors and antibiotic resistance and may cause thrombocytopenia. This study aimed to investigate the effects of different infections caused by K. pneumoniae on platelets. METHODS:Two hypermucoviscous K. pneumoniae strains and two classic s...

journal_title：Thrombosis research

authors： Wang Z,Ren J,Liu Q,Li J,Wu X,Wang W,Wu J,Wang G,Li J

更新日期：2018-11-01 00:00:00

abstract：INTRODUCTION:Procoagulant activity of heparanase has been recently described in several arterial and venous thrombotic disorders. In this study, we aimed to investigate the role of heparanase with regard to thrombus burden, thromboembolism, and treatment success with unfractionated heparin (UFH) in patients with prosth...

journal_title：Thrombosis research

authors： Bayam E,Kalçık M,Gürbüz AS,Yesin M,Güner A,Gündüz S,Gürsoy MO,Karakoyun S,Cerşit S,Kılıçgedik A,Candan Ö,Yaman A,Özkan M

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:The "HERDOO2 rule" is a prospectively validated clinical decision rule used to identify low-risk women who can safely discontinue anticoagulants after completing 5-12 months of anticoagulant treatment for unprovoked venous thromboembolism. The VIDAS®d-Dimer (DD) assay, a component of the rule, was used in th...

journal_title：Thrombosis research

authors： Rodger MA,Le Gal G,Langlois NJ,Gin B,Mallick R,Giulivi A,Freedman M,Kovacs MJ,REVERSE II investigators.

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:Cerebral vein thrombosis (CVT) is a rare, life-threatening disease affecting one adult per 100,000 per year. Genetic risk factors are deficiencies of the natural anticoagulant proteins antithrombin, protein C, protein S or single nucleotide polymorphisms such as factor V Leiden and prothrombin 20210A. In 20%...

journal_title：Thrombosis research

authors： Gorski MM,de Haan HG,Mancini I,Lotta LA,Bucciarelli P,Passamonti SM,Cairo A,Pappalardo E,van Hylckama Vlieg A,Martinelli I,Rosendaal FR,Peyvandi F

更新日期：2018-09-01 00:00:00

abstract：:Bone marrow transplantation (BMT) is the only curable option for thalassemia major, β-thalassemia/HbE. However, some patients still have the risk of hypercoagulable complications. We used a whole blood flow cytometric analysis to measure the circulating microparticle (MP) levels, activated platelets, and leukocyte-pla...

journal_title：Thrombosis research

authors： Klaihmon P,Lertthammakiat S,Anurathapan U,Pakakasama S,Sirachainan N,Hongeng S,Pattanapanyasat K

更新日期：2018-09-01 00:00:00

abstract：:Vascular endothelial injury (VEI) triggers pathological processes in various cardiovascular diseases, such as coronary heart disease and hypertension. To further elucidate the in vivo pathological mechanisms of VEI, many animal models have been established. For the easiness of genetic manipulation and feeding, murine ...

journal_title：Thrombosis research

authors： Wu Y,Su SA,Xie Y,Shen J,Zhu W,Xiang M

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVE:To compare rates of VTE occurrence in obese versus non-obese hospitalized patients who received UFH 5000 units subcutaneously q8 h. MATERIALS AND METHODS:This was a retrospective cohort study conducted in an academic medical center in the United States. Consecutive adult patients who were hospitalized during...

journal_title：Thrombosis research

authors： Patanwala AE,Seaman SM,Kopp BJ,Erstad BL

更新日期：2018-09-01 00:00:00

abstract：:Although significant advances in hemophilia treatment have improved patient outcomes and quality of life, one of the greatest complications in severe hemophilia A is the development of anti-Factor VIII (FVIII) antibodies that inhibit FVIII activity in almost 30% of previously untreated patients (PUPs). Inhibitors make...

journal_title：Thrombosis research

authors： Garagiola I,Palla R,Peyvandi F

更新日期：2018-08-01 00:00:00

abstract：INTRODUCTION:Adenosine diphosphate (ADP) as physiological activator of human platelets mediates its effects via three purinergic receptors: P2Y1, P2Y12 and P2X1. The inhibition of P2Y12 is used pharmacologically to suppress aggregation underlining the physiological significance of this receptor. Since the regulation of...

journal_title：Thrombosis research

authors： Koessler J,Trulley VN,Bosch A,Weber K,Koessler A,Boeck M,Kobsar A

更新日期：2018-08-01 00:00:00

abstract：INTRODUCTION:Venous thromboembolism (VTE) prophylaxis guidelines for non-surgical patients recommend VTE- and bleeding risk assessment to guide prophylactic strategies. These recommendations differ between guidelines and implementation is suboptimal. Assessing a guideline's implementability characteristics helps predic...

journal_title：Thrombosis research

authors： Moesker MJ,Damen NL,Volmeijer EE,Dreesens D,de Loos EM,Vink R,Coppens M,Kruip MJ,Meijer K,Langelaan M,de Bruijne MC,Wagner C

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:Our goal is to develop a vascular targeting treatment for brain arteriovenous malformations (AVMs). Externalized phosphatidylserine has been established as a potential biomarker on the endothelium of irradiated AVM blood vessels. We hypothesize that phosphatidylserine could be selectively targeted after AVM ...

journal_title：Thrombosis research

authors： Subramanian S,Ugoya SO,Zhao Z,McRobb LS,Grau GE,Combes V,Inglis DW,Gauden AJ,Lee VS,Moutrie V,Santos ED,Stoodley MA

更新日期：2018-07-01 00:00:00

abstract：INTRODUCTION:The effects of multiple inherited and acquired thrombophilic defects on the outcome of in-vitro fertilization (IVF) remain unexplored. The aim of this study was to evaluate the association between multiple thrombophilia and clinical outcomes in a large prospective cohort of women undergoing IVF. MATERIALS...

journal_title：Thrombosis research

authors： Di Nisio M,Ponzano A,Tiboni GM,Guglielmi MD,Rutjes AWS,Porreca E

更新日期：2018-07-01 00:00:00

abstract：INTRODUCTION:Ticagrelor and prasugrel are recommended as first line therapy in patients with acute coronary syndromes (ACS). However, patients with anemia are commonly treated with clopidogrel in routine clinical practice. The RENAMI registry (REgistry of New Antiplatelet therapy in patients with acute Myocardial Infar...

journal_title：Thrombosis research

authors： Guerrero C,Garay A,Ariza-Solé A,Formiga F,Raposeiras-Roubín S,Abu-Assi E,D'Ascenzo F,Kinnaird T,Manzano-Fernández S,Alegre O,Sánchez-Salado JC,Lorente V,Templin C,Velicki L,Xanthopoulou I,Cerrato E,Rognoni A,Boccuzzi G

更新日期：2018-07-01 00:00:00

abstract：:Platelet activation plays an important role in the development of sepsis. During sepsis, platelet activation leads to endothelial cell injury and promotes neutrophil extracellular trap and microthrombus formation, exacerbating septic coagulation and inflammatory reactions. The resultant induction or aggravation of dis...

journal_title：Thrombosis research

authors： Wang Y,Ouyang Y,Liu B,Ma X,Ding R

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:The methodology of thromboprophylaxis post minimally invasive esophagectomy (MIE) is unclear. Thus, we compared the efficacy and safety of fondaparinux and nadroparin on the prophylaxis of venous thromboembolism (VTE) after MIE. MATERIALS AND METHODS:We conducted a randomized, double-blind, treatment-contro...

journal_title：Thrombosis research

authors： Song J,Xuan L,Wu W,Shen Y,Tan L,Zhong M

更新日期：2018-06-01 00:00:00

abstract：INTRODUCTION:Profuse postpartum hemorrhage (PPH) and red blood cell (RBC) transfusion have been suggested to be associated with venous thromboembolic events (VTE). However, it is not fully clear if they are independent major risk factors. METHODS:Women who gave birth in the Stockholm area between 1999 and 2002 were th...

journal_title：Thrombosis research

authors： Thurn L,Wikman A,Lindqvist PG

更新日期：2018-05-01 00:00:00

abstract：INTRODUCTION:Increased levels of circulating tissue factor (TF)-positive microvesicles (MVs) may increase the risk of thrombosis. Indeed, TF-positive MVs are detected in plasma of patients with various types of diseases. In this study, we measured levels of MV TF activity in non-cancer severely ill patients and cancer ...

journal_title：Thrombosis research

authors： Hisada Y,Thålin C,Lundström S,Wallén H,Mackman N

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVES:Dabigatran etexilate is widely used for stroke prevention in the patients with atrial fibrillation. The anticoagulation activity of dabigatran is not necessary monitored in routine clinical practice. We aimed to study the effect of dabigatran on thrombin generation (TG) and coagulation assays in rabbit and h...

journal_title：Thrombosis research

authors： Zhang C,Zhang P,Li H,Han L,Zhang L,Zhang L,Yang X

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:Venous thromboembolism (VTE) can be the first manifestation of cancer; however, the current incidence of malignancy in unselected patients with first unprovoked VTE needs to be confirmed. MATERIAL AND METHODS:Between March 1st, 2013 and February 28th, 2015 we included and followed-up all patients living in ...

journal_title：Thrombosis research

authors： Delluc A,Ianotto JC,Tromeur C,De Moreuil C,Couturaud F,Lacut K,Le Moigne E,Louis P,Thereaux J,Metges JP,Mottier D

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to determine whether the administration of multiple boluses of oral and intravenous tranexamic acid (TXA) postoperatively was equivalent in reducing blood loss in primary THA. METHODS:A total of 108 patients were randomized into two groups: oral TXA group (54 patients receiving...

journal_title：Thrombosis research

authors： Cao G,Huang Z,Xie J,Huang Q,Xu B,Zhang S,Pei F

更新日期：2018-04-01 00:00:00